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GrimAge2

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Research algorithm, not a direct CRP or HbA1c assay and not a clinical diagnostic. Reported improvements in mortality and morbidity prediction are predictive-validation results, not evidence of clinical utility or individual treatment guidance. Sources verified 2026-09-28: https://www.aging-us.com/article/204434/text

Kind
Research mortality-risk algorithm
Type of test
Updated DNA-methylation composite estimator
Sample
Blood DNA methylation profiled on an Illumina array
Details
Second-generation GrimAge model using the same 1,030-CpG set and adding DNA-methylation estimators of log-transformed high-sensitivity C-reactive protein and hemoglobin A1C to the mortality-risk framework.
Publications
Lu et al., Aging (2022), DOI 10.18632/aging.204434