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DunedinPACE

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Research algorithm, not a commercial assay or clinical diagnostic. Reported associations with morbidity, disability, and mortality support predictive validity in research cohorts; they do not establish clinical utility or individual treatment guidance. Sources verified 2026-09-28: https://pubmed.ncbi.nlm.nih.gov/35029144/ ; https://moffittcaspi.trinity.duke.edu/dunedinpace

Kind
Research biological-aging algorithm
Type of test
DNA-methylation pace-of-aging estimator
Sample
Blood DNA methylation profiled on a compatible Illumina array
How to get
Research code is provided by the Moffitt-Caspi lab for Illumina 450K, EPIC1, and EPIC2 methylation data.
Details
Single-time-point DNA-methylation model derived with elastic-net regression from within-person change in 19 organ-system indicators measured at four time points across 20 years in the Dunedin birth cohort.
Publications
Belsky et al., eLife (2022), DOI 10.7554/eLife.73420