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Telomeres and Human Disease

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Official iBiology two-part lecture recorded in August 2016. De Lange explains telomere end protection, shelterin, telomerase, shortening, and how TRF2 and POT1 suppress ATM- and ATR-mediated DNA-damage responses at chromosome ends. Sources verified 2026-09-28: https://www.ibiology.org/genetics-and-gene-regulation/telomeres-and-human-disease/

Creator
Titia de Lange
Kind
Recorded scientific lecture series
Duration
1:14:51
Year
2016
Topic
Telomere shortening and maintenance, chromosome-end protection, shelterin, telomerase, ATM and ATR DNA-damage signaling, inappropriate DNA repair, cancer, and inherited telomere disorders