People

Telomere maintenance, nuclear DNA repair, mitochondrial DNA replication and repair, mutagenic end joining, and mitochondrial-nuclear stress signaling

Advanced glycation end products and their receptors, AGE-driven extracellular-matrix signaling, diabetic and age-related retinal disease, retinal neurovascular dysfunction, angiogenesis and vascular regeneration

Mitochondrial DNA mutations, mitochondrial stress signaling, organelle quality control, respiratory-chain maintenance, interorgan proteostasis and mitochondrial mechanisms of aging

Mitochondrial homeostasis, PINK1-Parkin mitophagy, mitochondrial DNA mutations, mitochondrial stress and immune signaling, metabolism, aging, and neurodegeneration

Extracellular-matrix biology, matrisome definition, ECM proteomics and bioinformatics, matrix composition in development and disease, and dissemination of ECM datasets and analytical tools

Autophagy, lysosomal protein degradation, proteostasis, and their decline in aging and age-related disorders

Lysosomal signaling, TFEB and the CLEAR gene network, lysosomal biogenesis, autophagy, intracellular clearance, metabolism, and lysosomal storage diseases

Life sciences, biotech, longevity, consumer wellness, digital health

Receptor for advanced glycation end products signaling, glycation-linked inflammation and oxidative stress, diabetes complications, obesity, vascular disease, and neurodegeneration

Selective and non-selective autophagy, autophagosome biogenesis, aggregate clearance, neuronal proteostasis, mitophagy, aging, neurodegeneration and cancer

Partial reprogramming, epigenetic reprogramming, longevity diagnostics, gene therapies, cancer reprogramming, polyphenols research

Regenerative medicine, stem cells, longevity, biotech incubation

Lysosome-autophagy regulation, selective autophagy and ER-phagy, lysosomal biogenesis, toxic intracellular material and misfolded-protein clearance, and lysosomal storage disorders

Telomerase and telomere-length regulation, chromosome-end protection, cellular senescence, telomere syndromes, DNA replication and telomere elongation

Advanced glycation end products, methylglyoxal and dicarbonyl stress, RAGE signaling, glycation of long-lived extracellular-matrix proteins, arterial stiffness, vascular inflammation, diabetes complications, and age-related chronic disease

Mitochondrial bioenergetics, nucleotide metabolism, genomic stability, cellular senescence, immune metabolism, and premature aging

Mitochondrial unfolded-protein response, mitochondrial stress signaling, organelle maintenance, and deleterious mitochondrial genome propagation during aging

Autophagy and lysosomal degradation, cargo recognition and trafficking, nutrient recycling, insulin sensitivity, exercise-induced metabolic benefits, aggregate-prone protein clearance, neuroinflammation, and age-related degenerative disease

Hematopoietic stem-cell niches, bone-marrow microenvironment dynamics, intravital imaging, infection- and leukemia-driven niche remodeling, stem-cell stress responses, and tissue regeneration

Mitochondrial stress responses, NAD-dependent metabolism, stem-cell aging, inflammaging, and therapeutic targets for age-related degeneration

Autophagy mechanisms, selective cytoplasm-to-vacuole targeting, autophagosome biogenesis, vacuolar protein trafficking, nutrient-stress responses, and autophagy measurement standards

Evolutionary ecology and genetics of aging, comparative senescence in wild vertebrates, longitudinal aging phenotypes, early-life environmental effects, immune aging, telomeres, survival and reproductive aging

Mitochondrial fusion and fission, mitochondrial quality and protein homeostasis, mtDNA integrity, organelle interactions, neuronal mitochondrial function, and mitochondrial mechanisms in human disease

Biogerontology, evolutionary theory of aging, C. elegans, senescence

Autophagy, aggregate-prone protein clearance, proteostasis, and neurodegenerative disease

Chemical biology of glucosepane and glycation-derived protein modifications, synthetic disease probes, and targeted degradation of extracellular proteins