Journals

Mechanisms connecting aging with cancer evolution and progression, including DNA damage and repair, genomic instability, epigenetics, senescence, stem-cell function, inflammation, metabolism, host microenvironments, and inter-organ communication.

Mechanisms underlying healthy and pathological brain aging, including signaling between the brain, other organs, and the external environment that affects mental healthspan.

Pathobiology of aging and age-related diseases, including molecular and cellular aging mechanisms, geriatric physiology and pathology, pharmacology, genetics, epidemiology, and therapeutic development.

Basic and clinical research on amyloids and systemic or localized amyloidosis, including protein structure, fibrillogenesis, disease mechanisms, genetics, pathology, diagnosis, and treatment.

Redox processes in health and disease, including oxidative signaling, structural biology, epigenetics, stem cells, regenerative medicine, and genetic, pharmaceutical, and nutritional redox-based therapeutics.

Autophagic processes and their links to human health and disease, including aging, neurodegeneration, cancer, diabetes, myopathies, and heart disease across experimental systems from yeast to humans.

Fundamental, translational, and clinical research on autophagic processes, lysosome- and vacuole-dependent degradation of intracellular material, and links between autophagy, aging, neurodegeneration, cancer, diabetes, myopathies, and heart disease.

Biological membranes in energy transfer and conversion, including mitochondrial respiration, oxidative phosphorylation, mitochondrial structure-function relationships, energy metabolism, mitochondrial disorders, and neurodegenerative disease.

Intracellular and intercellular signaling in health and disease, including protein interactions, epigenetic regulation, senescence, aging, autophagy, cell death, clearance of dying cells, and tissue-microenvironment responses.

Mechanistic and translational research at the intersection of cell death and medicine, spanning cell biology, biochemistry, pharmacology, immunology, neurobiology, inflammation, mitochondrial stress, and disease.

Basic and translational research in stem cells and regenerative biology, including cell reprogramming, adult stem and progenitor cells, organoids, tissue repair, and skeletal-muscle regeneration and aging.

Cellular pathology and stress biology, including pathological aging, mitochondriopathies, neurodegeneration, cancer, autophagy, mitophagy, proteostasis, genome stress, and fundamental through clinical research.

Cellular and organismal stress responses, molecular chaperones, proteostasis, caloristasis, intracellular and extracellular stress signaling, age-related deregulation of chaperone function, neurodegeneration, and therapeutic targeting of chaperone systems.

Mechanisms, technologies, and applications of cellular identity reversal or modification, including defined-factor reprogramming, nuclear transfer, cell fusion, stem cells, genome editing, disease modeling, and cell and gene therapy.

Chromosome, chromatin, and nuclear biology across organisms, including chromosome organization, DNA repair, epigenetics, cancer cytogenomics, comparative genomics, telomeres, and genome stability.

Clinical, genetic, and epidemiological research on companion-animal health and welfare, including disease risk, survival, breeding effects, diagnostics, and interventions across dogs, cats, horses, rodents, and other pets.

Connective-tissue and extracellular-matrix biology, including matrix structure-function relationships, cell-matrix interactions, mechanobiology, tissue repair, remodeling, regenerative medicine, and matrix changes in aging.

Aging from fundamental biology through clinical translation, including hallmarks of aging, senescence and SASP, genomics and epigenetics, mitochondria, proteostasis, stem cells, rejuvenation, biomarkers, interventions, frailty, and inflammaging.

Molecular and cellular biology spanning genetics, genomics, epigenetics, RNA, protein expression and degradation, organelles, mitochondrial biology, autophagy, apoptosis, inflammation, and molecular mechanisms of disease.

Genetic, cellular, biochemical, structural, and molecular aspects of DNA repair and cellular responses to DNA damage, including genome integrity, epigenetics, mutagenesis, aging, cancer, and neurological dysfunction.

Epigenetic mechanisms and chromatin-based regulation, including DNA methylation, cellular reprogramming, gene activation and silencing, nucleosome modification and remodeling, chromatin structure, and chromosome maintenance.

Redox biology in health and disease, including oxidative, reductive, nitrosative and redox stress, aging and age-related diseases, mitochondrial function and signaling, metabolic regulation, homeostatic adaptation, and antioxidant pathways.

Glycative stress across biochemical and medical research, including glycation, advanced glycation end products, oxidative interactions, metabolism, and aging-related tissue damage.

Mechanistic research in bioenergetics, biological membranes, and transport, including oxidative phosphorylation and studies linking cellular energetics to metabolic and neurodegenerative disease.

Cachexia, sarcopenia, muscle wasting, body composition, and physiological and pathological changes across the lifespan, including skeletal-muscle loss during aging and chronic disease.

Comparative physiology across invertebrate and vertebrate animals, integrating molecular, cellular, and systemic physiology with metabolism, energetics, endocrine biology, adaptation, and evolutionary physiology.

Extracellular vesicles and particles, their biogenesis and interactions with extracellular matrix and other macromolecules, intercellular and inter-organ communication, diagnostics, therapeutics, engineering, methods, and research resources.

Foundational, methodological, and translational extracellular-vesicle research, including EV biogenesis and signaling, intercellular and inter-organism communication, disease mechanisms, biomarkers, therapeutics, bioengineering, and clinical studies.

Inherited metabolic disorders in humans and higher animals across clinical, biochemical, genetic, cell-biological, experimental, diagnostic, and therapeutic research, including mitochondrial and lysosomal diseases.

Tissue engineering and regenerative approaches to repair or restore tissue and organ function, including biomaterials, extracellular-matrix scaffolds, cell microenvironments, fibrosis, and stem-cell-based regeneration.

Basic, translational, and clinical longevity research focused on disease prevention, healthspan, vitality, and preventive medicine, alongside technology, regulation, public policy, and population health.

Molecular components of the extracellular matrix and the biological effects of cell-matrix interactions, including matrix-related genetics, signaling, immunity, disease mechanisms, therapeutics, development, health, and disease.

Extracellular-matrix biology and cell-matrix interactions, including translational studies, research tools, proteomic datasets, signal transduction, genomics, bioengineering, disease mechanisms, and regenerative applications.

Basic and clinical mitochondrial biology, including mitochondrial dynamics and quality control, mitophagy-linked stress responses, organelle interactions, mitochondrial genetics, nucleus-mitochondria crosstalk, redox biology, cell metabolism, and aging-related diseases.

Mitochondrial DNA chemistry, biochemistry and integrity, proteins involved in mitochondrial-DNA metabolism, cytosolic and extracellular mitochondrial DNA, mitochondrial dysfunction, and methods for mitochondrial-DNA manipulation and analysis.

Basic mitochondrial science through pathology and clinical mitochondrial disease, spanning molecular and cell biology, genetics, metabolism, programmed cell death, aging, and cancer.

Basic and translational proteomics, including biological and clinical discoveries, protein and post-translational-modification measurement, mass-spectrometry methods, glycoproteomics, computational proteomics, and reproducible data standards.

Mechanistic and translational research in energy homeostasis and metabolic physiology across the lifespan, including nutrient sensing, cellular metabolism, mitochondrial function, metabolic disease, and associated long-term complications.

Molecular and cellular mechanisms of neurodegeneration in age-associated disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and glaucoma.

Mechanisms and consequences of genetic change, including DNA damage, DNA repair, genomic instability, mutations, epigenetic change, genomics, and molecular toxicology.

DNA mutations and epimutations, genome structural variation, chromosomal aberrations, aneuploidy, DNA damage and repair, replication and recombination, cellular senescence, genome instability, stem-cell fate, mitochondrial DNA mutations, and somatic mutation landscapes in aging.

Review scholarship across mutation research, with emphasis on mutation and disease, human-genome research, mutation detection, functional genomics, clinical genetics, genetic toxicology, and environmental mutagenesis.

Repair, replacement, and regeneration of damaged tissues and organs through stem-cell biology and therapies, cell and gene therapies, gene editing, tissue engineering, organoids, biomaterials, immune modulation, and translational studies, including age-related degenerative diseases.

Protein folding and misfolding, protein-assembly disorders, amyloid and prion biology, protein structural inheritance, and the propagation of pathogenic protein conformations.

Protein-centered research spanning protein structure, function, folding, molecular dynamics, synthesis, trafficking, sorting, interactions, regulation, mechanism, evolution, aggregation, and experimental and computational methods.

Oxidation-reduction processes in health and disease, including redox signaling, oxidative macromolecular damage, mitochondrial metabolism and quality, cellular senescence, aging, adaptive stress responses, and redox methods.

Basic discoveries, methods, and translational and clinical studies in stem-cell biology, regenerative medicine, tissue engineering, and related biomedical research.

Basic, translational, and clinical research into stem-cell therapeutics and regenerative therapies, including adult and pluripotent stem cells, genetics and epigenetics, disease modeling, cell manufacture, clinical studies, transplantation, biomaterials, and tissue engineering.

Stem-cell and organoid research covering embryonic and tissue-specific stem cells, induced pluripotent stem cells, cellular reprogramming, early development, disease modeling, cell and gene therapies, tissue engineering, regenerative medicine, and stem cells in aging.

Clinical translation of stem-cell and regenerative therapies, spanning mechanistic and preclinical validation, cell and gene therapies, biomaterials and tissue engineering, manufacturing, first-in-human studies, clinical trials, and implementation into practice.

Intracellular transport, membrane dynamics, organelle function and biogenesis, including autophagy, lysosomes, lysosomal storage diseases, intracellular proteolysis, protein quality control, and mitochondrial dynamics.