AagingBase
A manually curated comprehensive database for anti-aging peptides
Abertay Glycation Database
Literature-derived concentrations of non-enzymatic glycation compounds in foods and beverages, including free and protein-bound Amadori and Heyns compounds, dietary advanced glycation end products, and volatile Maillard-reaction compounds.Abertay UniversityPublic searchable database with food, molecule, combined advanced queries, and downloadable molecule and analytical-method information
Age-related diseases overview
An overview of age-related diseases incl. data on incidence, etiology, clinical trials, animal models, and more
AgeAnnoMO
Multi-omics annotations for animal aging across eight data modalities and 50 species, including aging-associated genes, proteins, metabolites, mitochondrial genes, microbiota, and age-specific T-cell and B-cell receptor sequences.Xiaobo Zhou laboratory, University of Texas Health Science Center at HoustonPublic searchable knowledgebase
Aging Atlas
Gene expression & regulation datasets created by a range of high-throughput omics. Includes several different modules, such as genes, transcriptomics, epigenomics, single-cell transcriptomics, proteomics, and pharmacogenomics.
Aging Fly Cell Atlas
Web portal for aging studies in Drosophila
Aging ReG
Manually curated database of aging factors, focusing on the regulatory relationships during aging with experimental evidence in human
Amyloid Explorer
Curated full-length amyloid-fibril core structures with protein and disease annotations, experimental method and resolution, disease-linked mutations, aggregation-prone regions, interactive three-dimensional polymorph comparisons and per-residue thermodynamic profiles.VIB-KU Leuven Switch LaboratoryFree public browse, visualization and downloads without an account; terms allow data access, download and use and permit redistribution of unmodified data files, with scholarly citation required in publications
AnAge
An aging-oriented animal database featuring over 4,000 species
Autophagy Database
Cross-species catalog of reviewed autophagy-related proteins, orthologues and homologues, with protein sequences, structures, Gene Ontology and literature annotations, keyword and homology search, and downloadable data dumps.National Institute of Genetics, JapanPublic searchable website and downloadable text and database-dump files
AutophagyNet
Integrated autophagy regulatory network combining manually curated core components with protein interactions, post-translational modifications, transcriptional and post-transcriptional regulators, signaling-pathway connections, tissue and subcellular annotations, and autophagy type and phase labels.Korcsmáros Lab and AutophagyNet collaboratorsPublic browse and customizable downloads in CSV, PSI-MI, BioPAX, SBML and Cytoscape formats
basement membraneBASE
Basement-membrane atlas and database connecting a 222-gene human basement-membrane-zone network with protein-localization evidence, component classes, human phenotypes and variants, animal-model data, experimental systems, reagents and protocols.University of Manchester and Duke University basement membraneBASE teamPublic resource pages, searchable database and downloadable gene-network data
BioGRID Autophagy Project
Themed BioGRID curation view for human autophagy, exposing literature-curated protein interactions, post-translational modifications and chemical interactions centered initially on macroautophagy, with a curated protein list and project-level downloadable files.BioGRID teamFree public query and tab-delimited project downloads under the BioGRID MIT License
Biolearn DNA methylation data sets
A number of useful DNA methylation data sets from GEO related to aging or age-related diseases
Canine Aging Atlas
Age-related changes in the canine transcriptome and proteome
CarbonylDB
Manually curated experimentally confirmed protein-carbonylation sites with protein and species annotations, residue positions, flanking sequences, experimental information, literature references, sequence search, and downloadable data.Digital Biology Laboratory, University of MissouriPublic searchable and downloadable web resource
Cell Atlas of Worm Aging
Comprehensive single-cell transcriptomic atlases spanning the entire lifespan of Caenorhabditis elegans under various pro-longevity conditions
CellAge
A curated database of human genes associated with cellular senescence
circAge
Aging-associated circular-RNA expression profiles across species, tissues, and age states, with differential-expression views, circRNA-miRNA and circRNA-RBP interaction predictions, coding potential, and conservation analysis.Kunming Institute of Zoology, Chinese Academy of SciencesPublic searchable web database
Clock Foundation DNA Methylation Age Calculator
Hosted analysis portal that applies published epigenetic clocks to Illumina human EPIC, 450K or 27K methylation data and HorvathMammalMethyl40 or MammalMethyl320 data, returning clock ages and optional age-acceleration, accuracy and quality-control measures.Steve Horvath and the Clock Foundation teamFree account registration is required to upload methylation data and a sample sheet; results are delivered by email and project dashboard, typically within 24–48 hours
ClockBase
Collection of gene expression and DNA methylation GEO datasets
COMADRE Animal Matrix Database
Literature-derived matrix population models and study metadata for animals, bacteria and viruses, supporting comparative analyses of survival, development, reproduction, life history and population dynamics across species and environments.COM(P)ADRE team, supported by Lincoln Park ZooOpen public exploration, query and versioned RData downloads without login under the Data User Agreement; optional registration provides release notifications
Complete cell atlas of C. elegans aging
Gene expression in nearly every somatic cell type across the adult lifespan of C. elegans. Data were collected at six different timepoints ranging from young to old adults
COSMIC Mutational Signatures
Expert-curated reference profiles for single-base substitutions, doublet-base substitutions, small insertions and deletions, copy-number changes and structural variants, with proposed aetiologies, tissue distributions, acceptance criteria, experimental signatures and downloadable numerical profiles.COSMIC and Cancer Grand Challenges with Wellcome Sanger Institute, University College London Pillay Lab and University of California Alexandrov Lab collaboratorsPublic signature browsing and download module, subject to COSMIC terms and conditions; hosted SigProfilerAssignment requires a free account
CPAD 2.0
Curated experimental data on amyloid and non-amyloid peptides, aggregation-prone regions, protein-aggregation kinetics and experimental conditions, and structures of aggregating proteins and ligand complexes, with associated prediction tools and downloads.Protein Bioinformatics Lab, Indian Institute of Technology MadrasPublic browse, statistics, tutorials and dataset downloads
CSGene
Literature-derived catalog of human cellular-senescence genes with evidence-ranked gene records, sequences, genomic locations, expression, mutations, pathways, diseases, functional annotations, PubMed evidence and downloadable nucleotide and protein sequences.CSGene authors and bioinfo-minzhao.orgPublic browse, text query, BLAST and academic-use downloads
Digital Ageing Atlas
The first centralized collection of aging changes and pathologies.
DNA Damage Atlas
Standardized repository of genome-wide sequencing data on DNA damage and repair, with dataset and sample metadata, quality control, hotspot identification, genome-browser tracks and analyses of repetitive regions including telomeres and ribosomal DNA.DNA Damage Atlas authors, Chinese Academy of Sciences collaboratorsFree public browse, search, visualization and data access
DNA Damage Response Assemblies Map Dataset
Archived mass-spectrometry and supporting data for a multi-scale map of DNA damage-response protein assemblies, including affinity-purification interaction profiles collected with and without genotoxin exposure and integrated analyses of repair, checkpoint and stress-response networks.Kratz, Kim, Krogan, Ideker and collaborators; archived by ProteomeXchange/PRIDEOpen ProteomeXchange metadata with downloadable PRIDE dataset files; associated paper and map annotations are publicly accessible
DrugAge
A curated database of compounds that modulate longevity in model organisms
EpiAge
Explore single-cell chromatin accessibility mouse data across different cell types, ages, and sexes.
EWAS Atlas
Curated epigenome-wide association knowledgebase organizing DNA-methylation associations and causal relationships by trait, CpG probe, gene, cohort, tissue, study and publication, with integrated retrieval, visualization and programmatic access.National Genomics Data Center, China National Center for BioinformationFree public search, browse, downloads and APIs within EWAS Open Platform
exBAClock
Structured catalog of published biological-aging clocks, their formulas and predictors, target populations and omics families, plus reported associations with diseases, mortality, lifestyle factors, and clinical trials.Institute of Biogerontology, Lobachevsky State UniversityPublic interactive web application
GenAge
A curated database of genes related to aging in humans and in model organisms
GenDR
The first database of dietary restriction-associated genes
Geroprotectors
The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others)
Healthy Worm Database
This site displays the results of a literature search for compounds tested for their effects on aging related phenotypes in the nematode Caenorhabditis elegans (C. elegans)
Human Aging and Longevity Landscape
Multi-modal human aging and longevity cohorts spanning young adults through centenarians, with curated omics datasets, aging and longevity genes, biomarkers, biological-age clocks, and cohort studies.China National Center for Bioinformation, Beijing Institute of Genomics, Chinese Academy of SciencesFree for academic use through the public web portal
Human Autophagy Database
Literature-based information on human genes and proteins involved directly or indirectly in autophagy, including genomic, structural, functional, interaction, and localization annotations.Luxembourg Institute of Health, Laboratory of Experimental Cancer ResearchPublic web database
Human Cell Aging Transcriptome Atlas
Standardized human single-cell RNA-sequencing repository spanning ages 0 to 103 across more than 50 tissue types, with sample search and downloads, an interactive genome browser for age-related differential expression, DEG prevalence views and Gene Ontology pathway-enrichment exploration.Masonic Institute on the Biology of Aging and Metabolism, University of MinnesotaPublic interactive web portal and downloadable sample matrices and metadata
Human DNA Repair Genes
Expert-maintained human DNA-repair gene tables organized by repair activity and pathway, with gene synonyms, biochemical activities, chromosome locations, accession identifiers, and links to GeneCards, OMIM and NCBI resources.Richard Wood Laboratory, University of Texas MD Anderson Cancer CenterPublic institutional web resource
Human Pluripotent Stem Cell Registry (hPSCreg)
Global registry of human embryonic and induced pluripotent stem-cell lines, including standardized identifiers, provenance, derivation and characterization metadata, donor-consent and permitted-use information, associated publications, providers, research projects and hPSC-based clinical studies.hPSCreg team at the Fraunhofer Institute for Biomedical EngineeringOfficial documentation describes public cell-line, project and clinical-study browsing, account-based registration and editing, and Data Access Committee review for sensitive genetic data. Direct portal access timed out during the September 28, 2026 check.
Human Protein Atlas Extracellular Matrix Secretome Subset
Human Protein Atlas filtered gene and protein resource for proteins classified as constituting or functioning in extracellular matrix, with functional categories, tissue-specific RNA expression, tissue protein detection and links to gene-level atlas records.Human Protein Atlas consortiumOpen public browse, search-result export and programmatic downloads under Human Protein Atlas terms
Human Proteostasis Network Annotation
Manually curated, gene-level annotation of the human proteostasis network across translation, protein folding and transport, mitochondrial, ER, nuclear, cytosolic and extracellular proteostasis, autophagy-lysosome pathways, and ubiquitin-proteasome systems.Proteostasis ConsortiumPublic web documentation and downloadable annotated spreadsheet
iLIR Autophagy Database
Predicted canonical LC3-interacting-region and Atg8-interacting-motif proteins across eight model organisms, with motif positions and scores, Gene Ontology annotations, keyword and motif search, enrichment views, BLAST, bibliography, and sequence-based LIR prediction.University of Warwick and University of Cyprus iLIR authorsFree public browse, search, BLAST and prediction tools
ITP longevity app
Web application that complements an ITP manuscript. The aim is to provide an easy and interactive access to the available data and results to enable hypothesis-building
ITP Results Summary
All compounds tested in the interventional testing program ITP, and their results
Longevity Interventions Database
List of interventions tested for lifespan currently via ITP or CITP (w/ goal of adding more sources), listing result & paper link plus other details.
LongevityMap
The first database of human genetic variants associated with longevity
Mammalian Methylation Data Browser
DNA methylation database that spans hundreds (~350) of mammalian species with maximum lifespan and phylogeny data
MatriComDB
Curated gene-pair database of extracellular-matrix to extracellular-matrix and cell to extracellular-matrix communications used by MatriCom to infer communication networks from single-cell RNA-sequencing data, with matrisome categories, localization and source-dependent reliability levels.Izzi Lab and Naba LabOpen download as an XLSX file within the GPL-3.0 MatriCom GitHub repository; also used by the public MatriCom Shiny application and installable R package
MatrisomeDB
Searchable extracellular-matrix proteomics data from normal and diseased tissues, with tissue detection, peptide coverage, post-translational modifications, and gene and protein cross-references.Naba and Gao labs, University of Illinois ChicagoPublic searchable database with data export
MatrixDB
Curated molecular interactions involving extracellular-matrix proteins, multimers, proteoglycans, glycosaminoglycans and bioactive matrix fragments, with experimental evidence, biomolecule annotations, tissue data, downloads and network exploration.SIB Swiss Institute of Bioinformatics, CNRS and Universite Lyon 1 collaboratorsPublic searchable database, downloadable datasets, API-backed portal, and network export
Metabolome Atlas of the Aging Mouse Brain
Metabolome atlas of the aging wildtype mouse brain from 10 anatomical regions spanning from adolescence to old age
MethAgingDB
Uniformly processed human and mouse DNA-methylation datasets across ages and tissues, with sample metadata, age-associated differentially methylated sites and regions, gene links, and a curated collection of aging clocks.Nankai University and Chinese PLA General HospitalPublic web database with downloadable matrices and metadata
MitImpact
Precomputed annotations and pathogenicity predictions for human mitochondrial DNA variants, covering protein-coding substitutions plus mitochondrial tRNA and rRNA variants, with multiple predictors, conservation, structural features, population frequencies and clinical-database annotations.Computational Biology and Bioinformatics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCSFree non-commercial web search, VCF annotation and downloads under CC BY-NC 4.0; commercial use requires permission
MitoAge
Curated comparative dataset linking animal mitochondrial-genome features to longevity records, including whole-genome, coding and non-coding region composition, gene-level features and codon usage for more than 900 species.Ben-Gurion University of the Negev Biology of Aging Laboratory and collaboratorsPublic browse, comparison tools and downloadable datasets
MitoCarta3.0
Human and mouse inventories of genes encoding mitochondrial proteins, with evidence of localization, sub-mitochondrial compartments, tissue distribution, and pathway annotations.Broad InstitutePublic web inventory and downloadable datasets
MITOMAP
Curated human mitochondrial-DNA resource covering sequence variation, population frequencies and haplogroups, reported disease-associated and somatic mutations, rearrangements, mitochondrial gene function, and literature references, with variant-search and sequence-analysis tools.Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of PhiladelphiaPublic web database, searches, analysis tools and data downloads
MitoMiner
Integrated mitochondrial-protein localization evidence from large-scale GFP-tagging and mass-spectrometry studies, targeting-sequence predictions, immunostaining, functional annotations, homology, phenotypes, pathways, tissue expression, and disease data.MRC Mitochondrial Biology Unit, University of CambridgePublic web resource with data-mining queries and reference sets
mitoXplorer 3.0
Interactive mitochondrial data-mining platform mapping gene-expression and mutation data onto manually curated mitochondrial interactomes and functional processes across human, mouse, fruit fly, and budding yeast.Developmental Biology Institute of Marseille, Aix-Marseille University and CNRSFree public web platform with hosted datasets, downloadable interactomes, and user data analysis
Mortality Predictors
MortalityPredictors.org is a database of human biomarkers associated with all-cause mortality in humans
Mouse Extracellular Matrix Proteome Atlas (PXD032000)
Mass-spectrometry dataset from extracellular-matrix-enriched fractions of 25 mouse organs, generated with an ECM-optimized three-step extraction workflow and including raw or processed files and study metadata for comparing matrisome proteins across tissues.MassIVE repository; dataset deposited by the Kirk Hansen laboratory at the University of Colorado Anschutz Medical CampusComplete Public MassIVE dataset with file browsing and download under CC0 1.0; no account is required to browse the dataset page or retrieve the public files
Mouse Ovarian Aging Single-Cell Atlas
Single-cell RNA sequencing dataset on ovarian tissue from young (3-month-old) and reproductively aged (9-month-old) mice
MSeqDR
Mitochondrial disease genome and phenome resource integrating mitochondrial and nuclear genes, variants, diseases, phenotypes, locus-specific records, population references, expert curation and analysis tools for variant annotation, haplogroups and exome or genome data.MSeqDR Consortium; hosted by Children's Hospital Los AngelesPublic search and browsing for many records and tools; registration or controlled access applies to submitted patient-level and collaborative data
Muscle Ageing Cell Atlas
Skeletal muscle aging atlas based on single-cell and single-nucleus sequencing data
NACDA: National Archive of Computerized Data on Aging
Data relevant to gerontological research. Curates data and documentation to promote effective research use, facilitate data sharing across the research community, and provide data user support for our hosted data collections.
ncRDeathDB
Noncoding-RNA-associated programmed-cell-death interactions across species, including an autophagy subset linking miRNAs, lncRNAs or snoRNAs with target genes, species, pathway classification, PubMed evidence and textual descriptions.College of Bioinformatics Science and Technology, Harbin Medical UniversityFree public search, browse, complete XLSX or text download, and a documented keyword or species-and-pathway API
Open Genes
Structured data on human genes associated with aging: functions, evolution, the influence of gene activity on lifespan, age-related changes in gene expression, associations of allelic variants of genes with longevity and age-related phenotype.
PanSci
An atlas comprising single-nucleus transcriptome profiles of 21,786,931 cells from >600 samples, covering 14 different tissues or organs across five life stages in both male and female mice.
PathoAge
Description of 33 million histological samples coupled with survival data
Phylobone
Cross-species bone extracellular-matrix protein resource organized into protein groups, with sequences, alignments, phylogenetic trees, functional domains, protein interactions, pathways, diseases and drug annotations for human and model-organism proteins.Pere Puigbò, Miho Nakamura and collaborators at the University of TurkuFree public browse by protein, phyletic pattern, species, domain, interaction, drug or disease
ProteomeHD
Human protein-abundance responses across 294 biological perturbations for 10,323 proteins, with searchable protein dashboards, covariation profiles, co-regulated partners and functional-enrichment views; the published co-regulation map covers 5,013 proteins.Rappsilber laboratory and ProteomeHD collaborators at the University of Edinburgh and Technische Universität BerlinPublic protein search and interactive dashboards without login; paper tables, analysis code and the PXD008888 repository provide downloadable data, while the current site's Data page is marked as work in progress
Reactome Cellular Senescence pathway
Peer-reviewed human pathway covering oncogene-induced, oxidative-stress-induced, and DNA-damage or telomere-stress-induced senescence, together with the senescence-associated secretory phenotype and linked molecular participants and events.ReactomePublic pathway browser with SBML, BioPAX, PDF, SVG, PNG, and orthology exports
Reactome DNA Repair Pathway
Expert-curated human DNA-repair pathway organized into molecular reactions and subpathways, with participating proteins and complexes, cellular compartments, supporting literature, interactive diagrams and exports in SBML, BioPAX, PDF, SVG and PNG formats.Reactome collaborationFree public pathway browsing and export without login; Reactome database data and derived data files are CC0, while pathway illustrations are CC BY 4.0
Reactome Mitophagy pathway
Reviewed human mitophagy pathway with PINK1-PRKN-mediated and receptor-mediated branches, linked molecular participants, component events, literature references, orthologous pathways, and exportable pathway models.ReactomePublic pathway browser with SBML, BioPAX, PDF, SVG, PNG, PPTX, and SBGN exports
Reactome Telomere Maintenance pathway
Curated human telomere-maintenance pathway with component events, participating molecules, literature references, orthologous pathways, and downloadable pathway formats.ReactomePublic pathway browser and downloads
Rodent Aging Interventions Database (RAID)
RAID provides a visual representation of the extension in lifespan achieved during published interventional studies in normally-aging rodents (mice and rats).
SASP Atlas
A comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types
Senequest
Information on gene-to-senescence associations generated by the Quertle Artifical Intelligence AI-powered literature search engine
SenNet Data Portal
Public datasets and atlases characterizing senescent cells across human and model-organism tissues, health states, and the lifespan, including annotated cell types and biomarkers.NIH Common Fund Cellular Senescence Network (SenNet)Public web portal
SenOmic
This transcriptomic database contains human fibroblast data from various senescence types, timepoints, treatments, cell lines and disease states which can all be filtered to generate data of interest
Single-Cell Atlas of Human Blood During Healthy Aging
Single-cell atlas of human blood during healthy aging
Single-cell RNA-seq Investigation of Rejuvenation Agens and Longevity (SINGULAR)
Cell rejuvenation atlas that provides a unified system biology analysis of diverse rejuvenation strategies across multiple organs at single-cell resolution.
SomaMutDB 2.0
Somatic single-nucleotide variants and small insertions or deletions reported in normal human tissues, with donor and sample metadata, gene and regulatory annotations, tissue expression context, mutational-signature tools, and functional-impact predictions.SomaMutDB team at the University of Minnesota and Albert Einstein College of MedicineOpen public browse, search, visualization and hg19/GRCh37 or hg38/GRCh38 dataset downloads; users can also submit variant files for analysis
Stemformatics
Quality-controlled, consistently processed gene-expression datasets focused on pluripotency, tissue stem cells, staged differentiation and hematopoietic lineages, with interactive expression views, cross-dataset comparisons, integrated atlases, metadata and expression downloads, and an API.Stemformatics team, University of Melbourne Centre for Stem Cell SystemsFree public portal, visualizations, downloads and API
Tabula muris senis
Single-cell and Bulk RNA-sequencing of different organs across the mouse lifespan
TeloBase
Community-curated catalog of experimentally confirmed, model-derived and sequencing-predicted telomere repeat sequences across the tree of life, with taxonomy, evidence status, source links, filters and evolutionary visualizations.CEITEC Masaryk University and TeloBase communityPublic interactive database; community submissions require peer approval
voyAGEr
Online graphical interface to explore age-related gene expression alterations in 49 human tissues
| Select up to four records | ||||
|---|---|---|---|---|
| AagingBase | A manually curated comprehensive database for anti-aging peptides | — | — | |
| Abertay Glycation Database | Literature-derived concentrations of non-enzymatic glycation compounds in foods and beverages, including free and protein-bound Amadori and Heyns compounds, dietary advanced glycation end products, and volatile Maillard-reaction compounds. | Abertay University | Public searchable database with food, molecule, combined advanced queries, and downloadable molecule and analytical-method information | |
| Age-related diseases overview | An overview of age-related diseases incl. data on incidence, etiology, clinical trials, animal models, and more | — | — | |
| AgeAnnoMO | Multi-omics annotations for animal aging across eight data modalities and 50 species, including aging-associated genes, proteins, metabolites, mitochondrial genes, microbiota, and age-specific T-cell and B-cell receptor sequences. | Xiaobo Zhou laboratory, University of Texas Health Science Center at Houston | Public searchable knowledgebase | |
| Aging Atlas | Gene expression & regulation datasets created by a range of high-throughput omics. Includes several different modules, such as genes, transcriptomics, epigenomics, single-cell transcriptomics, proteomics, and pharmacogenomics. | — | — | |
| Aging Fly Cell Atlas | Web portal for aging studies in Drosophila | — | — | |
| Aging ReG | Manually curated database of aging factors, focusing on the regulatory relationships during aging with experimental evidence in human | — | — | |
| Amyloid Explorer | Curated full-length amyloid-fibril core structures with protein and disease annotations, experimental method and resolution, disease-linked mutations, aggregation-prone regions, interactive three-dimensional polymorph comparisons and per-residue thermodynamic profiles. | VIB-KU Leuven Switch Laboratory | Free public browse, visualization and downloads without an account; terms allow data access, download and use and permit redistribution of unmodified data files, with scholarly citation required in publications | |
| AnAge | An aging-oriented animal database featuring over 4,000 species | — | — | |
| Autophagy Database | Cross-species catalog of reviewed autophagy-related proteins, orthologues and homologues, with protein sequences, structures, Gene Ontology and literature annotations, keyword and homology search, and downloadable data dumps. | National Institute of Genetics, Japan | Public searchable website and downloadable text and database-dump files | |
| AutophagyNet | Integrated autophagy regulatory network combining manually curated core components with protein interactions, post-translational modifications, transcriptional and post-transcriptional regulators, signaling-pathway connections, tissue and subcellular annotations, and autophagy type and phase labels. | Korcsmáros Lab and AutophagyNet collaborators | Public browse and customizable downloads in CSV, PSI-MI, BioPAX, SBML and Cytoscape formats | |
| basement membraneBASE | Basement-membrane atlas and database connecting a 222-gene human basement-membrane-zone network with protein-localization evidence, component classes, human phenotypes and variants, animal-model data, experimental systems, reagents and protocols. | University of Manchester and Duke University basement membraneBASE team | Public resource pages, searchable database and downloadable gene-network data | |
| BioGRID Autophagy Project | Themed BioGRID curation view for human autophagy, exposing literature-curated protein interactions, post-translational modifications and chemical interactions centered initially on macroautophagy, with a curated protein list and project-level downloadable files. | BioGRID team | Free public query and tab-delimited project downloads under the BioGRID MIT License | |
| Biolearn DNA methylation data sets | A number of useful DNA methylation data sets from GEO related to aging or age-related diseases | — | — | |
| Canine Aging Atlas | Age-related changes in the canine transcriptome and proteome | — | — | |
| CarbonylDB | Manually curated experimentally confirmed protein-carbonylation sites with protein and species annotations, residue positions, flanking sequences, experimental information, literature references, sequence search, and downloadable data. | Digital Biology Laboratory, University of Missouri | Public searchable and downloadable web resource | |
| Cell Atlas of Worm Aging | Comprehensive single-cell transcriptomic atlases spanning the entire lifespan of Caenorhabditis elegans under various pro-longevity conditions | — | — | |
| CellAge | A curated database of human genes associated with cellular senescence | — | — | |
| circAge | Aging-associated circular-RNA expression profiles across species, tissues, and age states, with differential-expression views, circRNA-miRNA and circRNA-RBP interaction predictions, coding potential, and conservation analysis. | Kunming Institute of Zoology, Chinese Academy of Sciences | Public searchable web database | |
| Clock Foundation DNA Methylation Age Calculator | Hosted analysis portal that applies published epigenetic clocks to Illumina human EPIC, 450K or 27K methylation data and HorvathMammalMethyl40 or MammalMethyl320 data, returning clock ages and optional age-acceleration, accuracy and quality-control measures. | Steve Horvath and the Clock Foundation team | Free account registration is required to upload methylation data and a sample sheet; results are delivered by email and project dashboard, typically within 24–48 hours | |
| ClockBase | Collection of gene expression and DNA methylation GEO datasets | — | — | |
| COMADRE Animal Matrix Database | Literature-derived matrix population models and study metadata for animals, bacteria and viruses, supporting comparative analyses of survival, development, reproduction, life history and population dynamics across species and environments. | COM(P)ADRE team, supported by Lincoln Park Zoo | Open public exploration, query and versioned RData downloads without login under the Data User Agreement; optional registration provides release notifications | |
| Complete cell atlas of C. elegans aging | Gene expression in nearly every somatic cell type across the adult lifespan of C. elegans. Data were collected at six different timepoints ranging from young to old adults | — | — | |
| COSMIC Mutational Signatures | Expert-curated reference profiles for single-base substitutions, doublet-base substitutions, small insertions and deletions, copy-number changes and structural variants, with proposed aetiologies, tissue distributions, acceptance criteria, experimental signatures and downloadable numerical profiles. | COSMIC and Cancer Grand Challenges with Wellcome Sanger Institute, University College London Pillay Lab and University of California Alexandrov Lab collaborators | Public signature browsing and download module, subject to COSMIC terms and conditions; hosted SigProfilerAssignment requires a free account | |
| CPAD 2.0 | Curated experimental data on amyloid and non-amyloid peptides, aggregation-prone regions, protein-aggregation kinetics and experimental conditions, and structures of aggregating proteins and ligand complexes, with associated prediction tools and downloads. | Protein Bioinformatics Lab, Indian Institute of Technology Madras | Public browse, statistics, tutorials and dataset downloads | |
| CSGene | Literature-derived catalog of human cellular-senescence genes with evidence-ranked gene records, sequences, genomic locations, expression, mutations, pathways, diseases, functional annotations, PubMed evidence and downloadable nucleotide and protein sequences. | CSGene authors and bioinfo-minzhao.org | Public browse, text query, BLAST and academic-use downloads | |
| Digital Ageing Atlas | The first centralized collection of aging changes and pathologies. | — | — | |
| DNA Damage Atlas | Standardized repository of genome-wide sequencing data on DNA damage and repair, with dataset and sample metadata, quality control, hotspot identification, genome-browser tracks and analyses of repetitive regions including telomeres and ribosomal DNA. | DNA Damage Atlas authors, Chinese Academy of Sciences collaborators | Free public browse, search, visualization and data access | |
| DNA Damage Response Assemblies Map Dataset | Archived mass-spectrometry and supporting data for a multi-scale map of DNA damage-response protein assemblies, including affinity-purification interaction profiles collected with and without genotoxin exposure and integrated analyses of repair, checkpoint and stress-response networks. | Kratz, Kim, Krogan, Ideker and collaborators; archived by ProteomeXchange/PRIDE | Open ProteomeXchange metadata with downloadable PRIDE dataset files; associated paper and map annotations are publicly accessible | |
| DrugAge | A curated database of compounds that modulate longevity in model organisms | — | — | |
| EpiAge | Explore single-cell chromatin accessibility mouse data across different cell types, ages, and sexes. | — | — | |
| EWAS Atlas | Curated epigenome-wide association knowledgebase organizing DNA-methylation associations and causal relationships by trait, CpG probe, gene, cohort, tissue, study and publication, with integrated retrieval, visualization and programmatic access. | National Genomics Data Center, China National Center for Bioinformation | Free public search, browse, downloads and APIs within EWAS Open Platform | |
| exBAClock | Structured catalog of published biological-aging clocks, their formulas and predictors, target populations and omics families, plus reported associations with diseases, mortality, lifestyle factors, and clinical trials. | Institute of Biogerontology, Lobachevsky State University | Public interactive web application | |
| GenAge | A curated database of genes related to aging in humans and in model organisms | — | — | |
| GenDR | The first database of dietary restriction-associated genes | — | — | |
| Geroprotectors | The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others) | — | — | |
| Healthy Worm Database | This site displays the results of a literature search for compounds tested for their effects on aging related phenotypes in the nematode Caenorhabditis elegans (C. elegans) | — | — | |
| Human Aging and Longevity Landscape | Multi-modal human aging and longevity cohorts spanning young adults through centenarians, with curated omics datasets, aging and longevity genes, biomarkers, biological-age clocks, and cohort studies. | China National Center for Bioinformation, Beijing Institute of Genomics, Chinese Academy of Sciences | Free for academic use through the public web portal | |
| Human Autophagy Database | Literature-based information on human genes and proteins involved directly or indirectly in autophagy, including genomic, structural, functional, interaction, and localization annotations. | Luxembourg Institute of Health, Laboratory of Experimental Cancer Research | Public web database | |
| Human Cell Aging Transcriptome Atlas | Standardized human single-cell RNA-sequencing repository spanning ages 0 to 103 across more than 50 tissue types, with sample search and downloads, an interactive genome browser for age-related differential expression, DEG prevalence views and Gene Ontology pathway-enrichment exploration. | Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota | Public interactive web portal and downloadable sample matrices and metadata | |
| Human DNA Repair Genes | Expert-maintained human DNA-repair gene tables organized by repair activity and pathway, with gene synonyms, biochemical activities, chromosome locations, accession identifiers, and links to GeneCards, OMIM and NCBI resources. | Richard Wood Laboratory, University of Texas MD Anderson Cancer Center | Public institutional web resource | |
| Human Pluripotent Stem Cell Registry (hPSCreg) | Global registry of human embryonic and induced pluripotent stem-cell lines, including standardized identifiers, provenance, derivation and characterization metadata, donor-consent and permitted-use information, associated publications, providers, research projects and hPSC-based clinical studies. | hPSCreg team at the Fraunhofer Institute for Biomedical Engineering | Official documentation describes public cell-line, project and clinical-study browsing, account-based registration and editing, and Data Access Committee review for sensitive genetic data. Direct portal access timed out during the September 28, 2026 check. | |
| Human Protein Atlas Extracellular Matrix Secretome Subset | Human Protein Atlas filtered gene and protein resource for proteins classified as constituting or functioning in extracellular matrix, with functional categories, tissue-specific RNA expression, tissue protein detection and links to gene-level atlas records. | Human Protein Atlas consortium | Open public browse, search-result export and programmatic downloads under Human Protein Atlas terms | |
| Human Proteostasis Network Annotation | Manually curated, gene-level annotation of the human proteostasis network across translation, protein folding and transport, mitochondrial, ER, nuclear, cytosolic and extracellular proteostasis, autophagy-lysosome pathways, and ubiquitin-proteasome systems. | Proteostasis Consortium | Public web documentation and downloadable annotated spreadsheet | |
| iLIR Autophagy Database | Predicted canonical LC3-interacting-region and Atg8-interacting-motif proteins across eight model organisms, with motif positions and scores, Gene Ontology annotations, keyword and motif search, enrichment views, BLAST, bibliography, and sequence-based LIR prediction. | University of Warwick and University of Cyprus iLIR authors | Free public browse, search, BLAST and prediction tools | |
| ITP longevity app | Web application that complements an ITP manuscript. The aim is to provide an easy and interactive access to the available data and results to enable hypothesis-building | — | — | |
| ITP Results Summary | All compounds tested in the interventional testing program ITP, and their results | — | — | |
| Longevity Interventions Database | List of interventions tested for lifespan currently via ITP or CITP (w/ goal of adding more sources), listing result & paper link plus other details. | — | — | |
| LongevityMap | The first database of human genetic variants associated with longevity | — | — | |
| Mammalian Methylation Data Browser | DNA methylation database that spans hundreds (~350) of mammalian species with maximum lifespan and phylogeny data | — | — | |
| MatriComDB | Curated gene-pair database of extracellular-matrix to extracellular-matrix and cell to extracellular-matrix communications used by MatriCom to infer communication networks from single-cell RNA-sequencing data, with matrisome categories, localization and source-dependent reliability levels. | Izzi Lab and Naba Lab | Open download as an XLSX file within the GPL-3.0 MatriCom GitHub repository; also used by the public MatriCom Shiny application and installable R package | |
| MatrisomeDB | Searchable extracellular-matrix proteomics data from normal and diseased tissues, with tissue detection, peptide coverage, post-translational modifications, and gene and protein cross-references. | Naba and Gao labs, University of Illinois Chicago | Public searchable database with data export | |
| MatrixDB | Curated molecular interactions involving extracellular-matrix proteins, multimers, proteoglycans, glycosaminoglycans and bioactive matrix fragments, with experimental evidence, biomolecule annotations, tissue data, downloads and network exploration. | SIB Swiss Institute of Bioinformatics, CNRS and Universite Lyon 1 collaborators | Public searchable database, downloadable datasets, API-backed portal, and network export | |
| Metabolome Atlas of the Aging Mouse Brain | Metabolome atlas of the aging wildtype mouse brain from 10 anatomical regions spanning from adolescence to old age | — | — | |
| MethAgingDB | Uniformly processed human and mouse DNA-methylation datasets across ages and tissues, with sample metadata, age-associated differentially methylated sites and regions, gene links, and a curated collection of aging clocks. | Nankai University and Chinese PLA General Hospital | Public web database with downloadable matrices and metadata | |
| MitImpact | Precomputed annotations and pathogenicity predictions for human mitochondrial DNA variants, covering protein-coding substitutions plus mitochondrial tRNA and rRNA variants, with multiple predictors, conservation, structural features, population frequencies and clinical-database annotations. | Computational Biology and Bioinformatics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCS | Free non-commercial web search, VCF annotation and downloads under CC BY-NC 4.0; commercial use requires permission | |
| MitoAge | Curated comparative dataset linking animal mitochondrial-genome features to longevity records, including whole-genome, coding and non-coding region composition, gene-level features and codon usage for more than 900 species. | Ben-Gurion University of the Negev Biology of Aging Laboratory and collaborators | Public browse, comparison tools and downloadable datasets | |
| MitoCarta3.0 | Human and mouse inventories of genes encoding mitochondrial proteins, with evidence of localization, sub-mitochondrial compartments, tissue distribution, and pathway annotations. | Broad Institute | Public web inventory and downloadable datasets | |
| MITOMAP | Curated human mitochondrial-DNA resource covering sequence variation, population frequencies and haplogroups, reported disease-associated and somatic mutations, rearrangements, mitochondrial gene function, and literature references, with variant-search and sequence-analysis tools. | Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia | Public web database, searches, analysis tools and data downloads | |
| MitoMiner | Integrated mitochondrial-protein localization evidence from large-scale GFP-tagging and mass-spectrometry studies, targeting-sequence predictions, immunostaining, functional annotations, homology, phenotypes, pathways, tissue expression, and disease data. | MRC Mitochondrial Biology Unit, University of Cambridge | Public web resource with data-mining queries and reference sets | |
| mitoXplorer 3.0 | Interactive mitochondrial data-mining platform mapping gene-expression and mutation data onto manually curated mitochondrial interactomes and functional processes across human, mouse, fruit fly, and budding yeast. | Developmental Biology Institute of Marseille, Aix-Marseille University and CNRS | Free public web platform with hosted datasets, downloadable interactomes, and user data analysis | |
| Mortality Predictors | MortalityPredictors.org is a database of human biomarkers associated with all-cause mortality in humans | — | — | |
| Mouse Extracellular Matrix Proteome Atlas (PXD032000) | Mass-spectrometry dataset from extracellular-matrix-enriched fractions of 25 mouse organs, generated with an ECM-optimized three-step extraction workflow and including raw or processed files and study metadata for comparing matrisome proteins across tissues. | MassIVE repository; dataset deposited by the Kirk Hansen laboratory at the University of Colorado Anschutz Medical Campus | Complete Public MassIVE dataset with file browsing and download under CC0 1.0; no account is required to browse the dataset page or retrieve the public files | |
| Mouse Ovarian Aging Single-Cell Atlas | Single-cell RNA sequencing dataset on ovarian tissue from young (3-month-old) and reproductively aged (9-month-old) mice | — | — | |
| MSeqDR | Mitochondrial disease genome and phenome resource integrating mitochondrial and nuclear genes, variants, diseases, phenotypes, locus-specific records, population references, expert curation and analysis tools for variant annotation, haplogroups and exome or genome data. | MSeqDR Consortium; hosted by Children's Hospital Los Angeles | Public search and browsing for many records and tools; registration or controlled access applies to submitted patient-level and collaborative data | |
| Muscle Ageing Cell Atlas | Skeletal muscle aging atlas based on single-cell and single-nucleus sequencing data | — | — | |
| NACDA: National Archive of Computerized Data on Aging | Data relevant to gerontological research. Curates data and documentation to promote effective research use, facilitate data sharing across the research community, and provide data user support for our hosted data collections. | — | — | |
| ncRDeathDB | Noncoding-RNA-associated programmed-cell-death interactions across species, including an autophagy subset linking miRNAs, lncRNAs or snoRNAs with target genes, species, pathway classification, PubMed evidence and textual descriptions. | College of Bioinformatics Science and Technology, Harbin Medical University | Free public search, browse, complete XLSX or text download, and a documented keyword or species-and-pathway API | |
| Open Genes | Structured data on human genes associated with aging: functions, evolution, the influence of gene activity on lifespan, age-related changes in gene expression, associations of allelic variants of genes with longevity and age-related phenotype. | — | — | |
| PanSci | An atlas comprising single-nucleus transcriptome profiles of 21,786,931 cells from >600 samples, covering 14 different tissues or organs across five life stages in both male and female mice. | — | — | |
| PathoAge | Description of 33 million histological samples coupled with survival data | — | — | |
| Phylobone | Cross-species bone extracellular-matrix protein resource organized into protein groups, with sequences, alignments, phylogenetic trees, functional domains, protein interactions, pathways, diseases and drug annotations for human and model-organism proteins. | Pere Puigbò, Miho Nakamura and collaborators at the University of Turku | Free public browse by protein, phyletic pattern, species, domain, interaction, drug or disease | |
| ProteomeHD | Human protein-abundance responses across 294 biological perturbations for 10,323 proteins, with searchable protein dashboards, covariation profiles, co-regulated partners and functional-enrichment views; the published co-regulation map covers 5,013 proteins. | Rappsilber laboratory and ProteomeHD collaborators at the University of Edinburgh and Technische Universität Berlin | Public protein search and interactive dashboards without login; paper tables, analysis code and the PXD008888 repository provide downloadable data, while the current site's Data page is marked as work in progress | |
| Reactome Cellular Senescence pathway | Peer-reviewed human pathway covering oncogene-induced, oxidative-stress-induced, and DNA-damage or telomere-stress-induced senescence, together with the senescence-associated secretory phenotype and linked molecular participants and events. | Reactome | Public pathway browser with SBML, BioPAX, PDF, SVG, PNG, and orthology exports | |
| Reactome DNA Repair Pathway | Expert-curated human DNA-repair pathway organized into molecular reactions and subpathways, with participating proteins and complexes, cellular compartments, supporting literature, interactive diagrams and exports in SBML, BioPAX, PDF, SVG and PNG formats. | Reactome collaboration | Free public pathway browsing and export without login; Reactome database data and derived data files are CC0, while pathway illustrations are CC BY 4.0 | |
| Reactome Mitophagy pathway | Reviewed human mitophagy pathway with PINK1-PRKN-mediated and receptor-mediated branches, linked molecular participants, component events, literature references, orthologous pathways, and exportable pathway models. | Reactome | Public pathway browser with SBML, BioPAX, PDF, SVG, PNG, PPTX, and SBGN exports | |
| Reactome Telomere Maintenance pathway | Curated human telomere-maintenance pathway with component events, participating molecules, literature references, orthologous pathways, and downloadable pathway formats. | Reactome | Public pathway browser and downloads | |
| Rodent Aging Interventions Database (RAID) | RAID provides a visual representation of the extension in lifespan achieved during published interventional studies in normally-aging rodents (mice and rats). | — | — | |
| SASP Atlas | A comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types | — | — | |
| Senequest | Information on gene-to-senescence associations generated by the Quertle Artifical Intelligence AI-powered literature search engine | — | — | |
| SenNet Data Portal | Public datasets and atlases characterizing senescent cells across human and model-organism tissues, health states, and the lifespan, including annotated cell types and biomarkers. | NIH Common Fund Cellular Senescence Network (SenNet) | Public web portal | |
| SenOmic | This transcriptomic database contains human fibroblast data from various senescence types, timepoints, treatments, cell lines and disease states which can all be filtered to generate data of interest | — | — | |
| Single-Cell Atlas of Human Blood During Healthy Aging | Single-cell atlas of human blood during healthy aging | — | — | |
| Single-cell RNA-seq Investigation of Rejuvenation Agens and Longevity (SINGULAR) | Cell rejuvenation atlas that provides a unified system biology analysis of diverse rejuvenation strategies across multiple organs at single-cell resolution. | — | — | |
| SomaMutDB 2.0 | Somatic single-nucleotide variants and small insertions or deletions reported in normal human tissues, with donor and sample metadata, gene and regulatory annotations, tissue expression context, mutational-signature tools, and functional-impact predictions. | SomaMutDB team at the University of Minnesota and Albert Einstein College of Medicine | Open public browse, search, visualization and hg19/GRCh37 or hg38/GRCh38 dataset downloads; users can also submit variant files for analysis | |
| Stemformatics | Quality-controlled, consistently processed gene-expression datasets focused on pluripotency, tissue stem cells, staged differentiation and hematopoietic lineages, with interactive expression views, cross-dataset comparisons, integrated atlases, metadata and expression downloads, and an API. | Stemformatics team, University of Melbourne Centre for Stem Cell Systems | Free public portal, visualizations, downloads and API | |
| Tabula muris senis | Single-cell and Bulk RNA-sequencing of different organs across the mouse lifespan | — | — | |
| TeloBase | Community-curated catalog of experimentally confirmed, model-derived and sequencing-predicted telomere repeat sequences across the tree of life, with taxonomy, evidence status, source links, filters and evolutionary visualizations. | CEITEC Masaryk University and TeloBase community | Public interactive database; community submissions require peer approval | |
| voyAGEr | Online graphical interface to explore age-related gene expression alterations in 49 human tissues | — | — |